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Current Approaches Fall Short
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FDA-approved opioid receptor antagonists such as Naloxone can reverse the most serious life-threatening opioid-induced side effects, but they:
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- Also reverse the pain relief, leaving patients in agony
- Are short-acting, requiring continuous re-administration
- Are only weakly effective against synthetic opioids like fentanyl
- Do nothing to modulate addiction
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Most ongoing research to minimize side effects is focused on direct targeting of opioid receptors – these efforts have largely not been successful.
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