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Current Approaches Fall Short

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FDA-approved opioid receptor antagonists such as Naloxone can reverse the most serious life-threatening opioid-induced side effects, but they:

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• Also reverse the pain relief, leaving patients in agony
• Are short-acting, requiring continuous re-administration
• Are only weakly effective against synthetic opioids like fentanyl
• Do nothing to modulate addiction

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Most ongoing research to minimize side effects is focused on direct targeting of opioid receptors – these efforts have largely not been successful.

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