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In-vitro and animal data show pre-clinical proof of concept.
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Click Here For Pre-Clinical Proof of Concept
[/vc_column_text][vc_column_text]ATLX-0190 is active on ventilatory control systems.
– Elicits substantial increases in minute ventilation, diaphragmatic-EMG (DIA-EMG), genioglossus-EMG (GG-EMG) with minor changes in mean arterial blood pressure (MABP) in freely moving and in isoflurane-anesthetized naïve rats
ATLX-0190 reverses the ventilatory-depressant effects of morphine in freely-moving rats.
– Elicits a sustained reversal of morphine-induced decrease in Minute Ventilation
– Elicits a sustained reversal of morphine-induced decrease in Peak Inspiratory Flow
– Elicits a sustained reversal of morphine-induced decrease in Inspiratory Drive
ATLX-0190 reverses the negative effects of morphine on arterial blood-gas chemistry in freely-moving rats.
– Reverses morphine-induced decreases in blood pH
– Modulates morphine-induced changes in pCO2, pO2, sO2, and the A-a gradient
– Reverses morphine-induced decreases in blood pH
– Modulates morphine-induced changes in pCO2, pO2, sO2, and the A-a gradient[/vc_column_text][/vc_column][vc_column width=”1/2″][vc_column_text]
Click Here For Appendices
[/vc_column_text][vc_column_text]ATLX-0190 does not effect opioid-induced analgesia in freely-moving rats.
ATLX-0190 diminishes withdrawal responses in morphine-dependent rats.
ATLX-0190 may modulate addiction.
Co-infusion of ATLX-0190 with morphine reduces NLX-precipitated withdrawal in morphine-dependent rats.
Acute co-administration of ATLX-0190 with NLX reduces NLX-precipitated withdrawal in morphine-dependent rats.
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