Based on overall chemical stability, efficacy, negligible cardiovascular effects, and onset profiles, ATLX-0199 (D-Cystine diME) was selected as the lead compound for clinical development, with back-up compounds available. ATLX-0199 safely stimulates opioid-depressed respiratory drive without interfering with opioid-induced analgesia.
Minute ventilation (VE) is the total volume of gas entering (or leaving) the lung per/min
It is equal to the tidal volume (TV) multiplied by the respiratory frequency rate (f).
VE = TV x f
Studied blood gas parameters include:
Increases in CO2
Oxygen imbalance between lungs and arteries